International Task Force for Prevention of
Coronary Heart Disease

CORONARY HEART DISEASE: REDUCING THE RISK

4.2 Mechanisms of atherogenesis

• Libby P (1995) Molecular bases of the acute coronary syndromes. Circulation 91:2844-2850

Comment: Scholarly review of biochemical and cellular processes in the atherosclerotic lesion that underlie acute coronary occlusive events. Inflammatory processes, perhaps promoted by oxidised LDL, contribute to thinning and rupture of the plaque’s fibrous cap and thrombotic occlusion